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KMID : 1207720180100020225
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Clinics in Orthopedic Surgery
2018 Volume.10 No. 2 p.225 ~ p.233
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Role of Nonsteroidal Anti-inflammatory Drug in Treatment of Extra-abdominal Desmoid Tumors
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Cho Ja-Young
Gupta Sanjay
Cho Hwan-Seong
Park Min-Suk
Mok Su-Jung
Han Il-Kyu
Kim Han-Soo
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Abstract
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Background: We retrospectively reviewed the outcomes of patients who had been treated with meloxicam for the extra-abdominal desmoid tumors and evaluated the correlation between clinical outcome and clinic pathological variables.
Methods: Twenty patients treated with meloxicam were followed up every 3 to 6 months. Meloxicam administration was planned at 15 mg/day orally for 6 months.
Results: Of the 20 patients evaluated, according to Response Evaluation Criteria in Solid Tumors criteria, there were five patients with partial response (25.0%), eight with stable disease (40.0%), and seven with tumor progression (35.0%). The cumulative probability of dropping out from our nonsurgical strategy using meloxicam was 35.0% at 1 year and 35.0% at 5 years.
Conclusions: The present study suggests that conservative treatment would be a primary treatment option for this perplexing disease even though we were not able to determine that the use of a cyclooxygenase-2 inhibitor would have an additional influence on the natural course of a desmoid tumor.
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KEYWORD
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Extra-abdominal desmoid tumors, Nonsteroidal anti-inflammatory drug
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